Increased Fibroblast Growth Factor 23 in Heart Failure: Biomarker, Mechanism, or Both?
نویسندگان
چکیده
منابع مشابه
Fibroblast growth factor 23: friend or foe in uremia?
Uremia is a complex metabolic state marked by derangement of many signaling molecules and metabolic intermediates; of these, the massively increased levels of FGF23 are among the most striking. It has remained unclear whether FGF23 is directly implicated in the pathogenesis of chronic kidney disease (CKD) and its complications, a consequence of other dysregulated pathways, or perhaps an adaptiv...
متن کاملCan Fibroblast Growth Factor-23 Improve Prognostication in Heart Failure Patients?
Fibroblast growth factor-23 (FGF-23) is a phosphate regulatory 251-aminoacid hormone secreted by osteocytes and acts as regulator phosphorus reabsorption in the proximal tubule of nephron and 1,25-dihydroxyvitamin D synthesis. Recent clinical studies have shown that higher serum FGF-23 levels are associated with subclinical cardiovascular (CV) disease, with new Heart Failure (HF) and chronic ki...
متن کاملFibroblast Growth Factor-23 Fans the Flames of Heart and Kidney Failure.
SEE PAGE 829 C hronic kidney disease (CKD) promotes cardiac injury, and heart failure begets kidney injury. Although shared risk factors such as diabetes, hypertension, and atherosclerosis are wellknown igniters of the combustible interaction between chronic heart and kidney diseases, identification of the accelerants that drive the full-fledged public health conflagration of “cardiorenal” dise...
متن کاملFibroblast Growth Factor‐23 and Incident Coronary Heart Disease, Heart Failure, and Cardiovascular Mortality: The Atherosclerosis Risk In Communities Study
BACKGROUND Fibroblast growth factor-23 (FGF-23) is a hormone involved in phosphorous regulation and vitamin D metabolism that may be associated with cardiovascular risk, and it is a potential target for intervention. We tested whether elevated FGF-23 is associated with incident coronary heart disease, heart failure, and cardiovascular mortality, even at normal kidney function. METHODS AND RES...
متن کاملHow fibroblast growth factor 23 works.
There is a discontinuum of hereditary and acquired disorders of phosphate homeostasis that are caused by either high or low circulating levels of the novel phosphaturic hormone fibroblastic growth factor 23 (FGF23). Disorders that are caused by high circulating levels of FGF23 are characterized by hypophosphatemia, decreased production of 1,25-dihydroxyvitamin D, and rickets/osteomalacia. On th...
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ژورنال
عنوان ژورنال: American Journal of Hypertension
سال: 2018
ISSN: 0895-7061,1941-7225
DOI: 10.1093/ajh/hpy153